Embryonic expression and activity of doughnut, a second RYK homolog in Drosophila

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Embryonic expression and activity of doughnut, a second RYK homolog in Drosophila

In the Drosophila embryo, a subset of muscles require expression and function of the RYK subfamily RTK gene derailed (drl) for correct attachment. We have isolated a second RYK homolog, doughnut (dnt), from Drosophila. The DNT protein exhibits 60% amino acid identity to DRL, and is structurally as similar to the mammalian RYK proteins as is DRL, indicating an ancient duplication event. dnt is e...

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ژورنال

عنوان ژورنال: Mechanisms of Development

سال: 1998

ISSN: 0925-4773

DOI: 10.1016/s0925-4773(98)00167-1